Geplaatst: ma dec 10, 2007 11:08 am
Hi Verona,
When does he take his last MSM?
After five o`clock in the afternoon he should not take any MSM, because it keeps him awake.
He also can try,
Valerian. Preparations made from the roots of valerian (Valeriana officinalis) have long been relied on to hasten refreshing sleep. Controlled studies show that valerian decreases the amount of time it takes to fall asleep, as well as the subjective quality of sleep, compared to placebo. Valerian also improves quality of sleep; at least one study has shown that valerian increases the percentage of time participants spend in slow-wave sleep. This is significant because slow-wave sleep is considered the most One recent multicenter, double-blind, randomized parallel group study compared valerian, 600 mg/day, to the commonly prescribed tranquilizer oxazepam (Serax®). Valerian was at least as effective (Ziegler G et al 2002).
While valerian is generally considered safe (Krystal AD et al 2001), the same cannot be said of most hypnotic drugs. “Long-term use of hypnotic agents can become complicated by drug tolerance, dependence, or rebound insomnia,” noted one scientist (Kirkwood CK 1999). Prescription drugs such as Valium® may cause morning “hangover”: fogginess of the mind, lethargy, clumsiness, and other symptoms. Valerian has consistently been shown to have no such side effects. In a randomized, controlled, double-blind study, researchers administered 600 mg valerian extract to 102 participants. The following morning, participants’ reaction times, alertness, and concentration were evaluated. Researchers found no negative effects on any objective parameters of alertness or ability to concentrate subsequent to single or multiple doses of valerian (Kuhlmann J et al 1999).
More recently, researchers examined the effects of exceptionally high doses of valerian (up to 1800 mg) on parameters relating to “hangover” versus diazepam (Xanax®) or placebo. The researchers concluded that valerian extract had no significant effects on any of the dependent measures. In contrast, the prescription drug impaired cognitive performance and affected mood (Gutierrez S et al 2004).
Traditionally, patients have been advised to take valerian for up to two weeks before expecting it to become fully effective. It is unclear whether this is truly necessary, however, as the clinical evidence is contradictory (Hadley S et al 2003).
Valerian contains the amino acid GABA, which could directly cause sedation. GABA acts as a neurotransmitter involved in regulation of relaxation, anxiety, and sleep. Valerian is also known to interact with GABA already active in the brain. Valerian prompts the release of GABA and inhibits enzymes involved in GABA’s breakdown, thus further increasing levels of this “relaxation neurotransmitter” (Cavadas C et al 1995; Yuan CS et al 2004).
Although it does not regulate sale or production of valerian, the Food and Drug Administration (FDA) lists valerian as “Generally Recognized as Safe.” No significant drug interactions have been reported, although valerian might increase the sedating effects of barbiturates or anesthesia drugs (Yuan CS et al 2004). It is also possible, although not definitively established, that valerian affects the metabolism of some other drugs in a manner similar to grapefruit (Donovan JL et al 2004; Lefebvre T et al 2004). Valerian has also been associated with liver damage, although purified extract of valerian appears to be safe for the liver.
Most published studies have found valerian effective for the treatment of insomnia when root extract equivalent to 300 to 600 mg is taken 30 minutes to two hours before intended bedtime. A study of valerian pharmacokinetics—the rate at which active constituents enter the bloodstream and are subsequently eliminated from the body—confirmed the effectiveness of this dosing regimen (Anderson GD et al 2005).
Lemon balm. Lemon balm (Melissa officinalis L) is often paired with valerian. A recently published study of a combination of valerian and lemon balm for the treatment of restlessness and disordered sleep in children found “a distinct and convincing reduction in severity . . . for all symptoms in the investigators’ and parents’ ratings” (Muller SF et al 2006). About 81 percent of patients with sleep disorders experienced improvement of their symptoms after taking the study preparation.
Lemon balm appears to work by reducing anxiety. A recent double-blind, placebo-controlled, randomized, balanced crossover experiment showed that a 600-mg dose of lemon balm improved the negative mood effects of a standardized procedure designed to induce stress under laboratory conditions. Participants taking lemon balm had “significantly increased self-ratings of calmness,” noted the researchers. “In addition, a significant increase in the speed of mathematical processing, with no reduction in accuracy, was observed after ingestion of the 300-mg dose” (Kennedy DO et al 2004).
The following lifestyle changes may relieve insomnia:
Avoid caffeine at least six hours before bedtime.
Avoid alcohol or smoking for two hours before bedtime.
Get regular exercise, but do not exercise within three hours of bedtime.
Establish regular bedtime and waking hours.
Do not work in the bedroom.
Consider using white-noise generators or relaxing music to “turn off” your mind.
If natural sleep remedies do not restore refreshing sleep, pharmaceutical drugs are available, including Klonopin®, Ambien®, Lunesta®, and many others. These drugs must be prescribed by a physician.
In addition, dehydroepiandrosterone (DHEA) replacement therapy may be recommended. Almost all aging humans are deficient in DHEA, and DHEA may help reduce cortisol levels and produce a feeling of well-being. Although DHEA has not been studied in insomnia, a suggested starting dose of 15 to 75 mg, followed by blood testing after three to six weeks, is recommended to promote peace of mind. It is important to take DHEA in the morning as taking it at night can be stimulatory.
greetings,
Corrij
When does he take his last MSM?
After five o`clock in the afternoon he should not take any MSM, because it keeps him awake.
He also can try,
Valerian. Preparations made from the roots of valerian (Valeriana officinalis) have long been relied on to hasten refreshing sleep. Controlled studies show that valerian decreases the amount of time it takes to fall asleep, as well as the subjective quality of sleep, compared to placebo. Valerian also improves quality of sleep; at least one study has shown that valerian increases the percentage of time participants spend in slow-wave sleep. This is significant because slow-wave sleep is considered the most One recent multicenter, double-blind, randomized parallel group study compared valerian, 600 mg/day, to the commonly prescribed tranquilizer oxazepam (Serax®). Valerian was at least as effective (Ziegler G et al 2002).
While valerian is generally considered safe (Krystal AD et al 2001), the same cannot be said of most hypnotic drugs. “Long-term use of hypnotic agents can become complicated by drug tolerance, dependence, or rebound insomnia,” noted one scientist (Kirkwood CK 1999). Prescription drugs such as Valium® may cause morning “hangover”: fogginess of the mind, lethargy, clumsiness, and other symptoms. Valerian has consistently been shown to have no such side effects. In a randomized, controlled, double-blind study, researchers administered 600 mg valerian extract to 102 participants. The following morning, participants’ reaction times, alertness, and concentration were evaluated. Researchers found no negative effects on any objective parameters of alertness or ability to concentrate subsequent to single or multiple doses of valerian (Kuhlmann J et al 1999).
More recently, researchers examined the effects of exceptionally high doses of valerian (up to 1800 mg) on parameters relating to “hangover” versus diazepam (Xanax®) or placebo. The researchers concluded that valerian extract had no significant effects on any of the dependent measures. In contrast, the prescription drug impaired cognitive performance and affected mood (Gutierrez S et al 2004).
Traditionally, patients have been advised to take valerian for up to two weeks before expecting it to become fully effective. It is unclear whether this is truly necessary, however, as the clinical evidence is contradictory (Hadley S et al 2003).
Valerian contains the amino acid GABA, which could directly cause sedation. GABA acts as a neurotransmitter involved in regulation of relaxation, anxiety, and sleep. Valerian is also known to interact with GABA already active in the brain. Valerian prompts the release of GABA and inhibits enzymes involved in GABA’s breakdown, thus further increasing levels of this “relaxation neurotransmitter” (Cavadas C et al 1995; Yuan CS et al 2004).
Although it does not regulate sale or production of valerian, the Food and Drug Administration (FDA) lists valerian as “Generally Recognized as Safe.” No significant drug interactions have been reported, although valerian might increase the sedating effects of barbiturates or anesthesia drugs (Yuan CS et al 2004). It is also possible, although not definitively established, that valerian affects the metabolism of some other drugs in a manner similar to grapefruit (Donovan JL et al 2004; Lefebvre T et al 2004). Valerian has also been associated with liver damage, although purified extract of valerian appears to be safe for the liver.
Most published studies have found valerian effective for the treatment of insomnia when root extract equivalent to 300 to 600 mg is taken 30 minutes to two hours before intended bedtime. A study of valerian pharmacokinetics—the rate at which active constituents enter the bloodstream and are subsequently eliminated from the body—confirmed the effectiveness of this dosing regimen (Anderson GD et al 2005).
Lemon balm. Lemon balm (Melissa officinalis L) is often paired with valerian. A recently published study of a combination of valerian and lemon balm for the treatment of restlessness and disordered sleep in children found “a distinct and convincing reduction in severity . . . for all symptoms in the investigators’ and parents’ ratings” (Muller SF et al 2006). About 81 percent of patients with sleep disorders experienced improvement of their symptoms after taking the study preparation.
Lemon balm appears to work by reducing anxiety. A recent double-blind, placebo-controlled, randomized, balanced crossover experiment showed that a 600-mg dose of lemon balm improved the negative mood effects of a standardized procedure designed to induce stress under laboratory conditions. Participants taking lemon balm had “significantly increased self-ratings of calmness,” noted the researchers. “In addition, a significant increase in the speed of mathematical processing, with no reduction in accuracy, was observed after ingestion of the 300-mg dose” (Kennedy DO et al 2004).
The following lifestyle changes may relieve insomnia:
Avoid caffeine at least six hours before bedtime.
Avoid alcohol or smoking for two hours before bedtime.
Get regular exercise, but do not exercise within three hours of bedtime.
Establish regular bedtime and waking hours.
Do not work in the bedroom.
Consider using white-noise generators or relaxing music to “turn off” your mind.
If natural sleep remedies do not restore refreshing sleep, pharmaceutical drugs are available, including Klonopin®, Ambien®, Lunesta®, and many others. These drugs must be prescribed by a physician.
In addition, dehydroepiandrosterone (DHEA) replacement therapy may be recommended. Almost all aging humans are deficient in DHEA, and DHEA may help reduce cortisol levels and produce a feeling of well-being. Although DHEA has not been studied in insomnia, a suggested starting dose of 15 to 75 mg, followed by blood testing after three to six weeks, is recommended to promote peace of mind. It is important to take DHEA in the morning as taking it at night can be stimulatory.
greetings,
Corrij